Publications ToxOmics

2015

2014

2013

Mechanistic insights into glycidamide-induced cytotoxic and genotoxic effects in human mammary cells. Bandarra S, Fernandes AS, Magro I, Guerreiro PS, Pingarilho M, Churchwell MI, Gil OM, Batinić-Haberle I, Gonçalves S, Rueff J, Miranda JP, Marques MM, Beland FA, Castro M, Gaspar JF,Oliveira NG. Mutagenesis. 2013; 28(6):721-9.

http://www.ncbi.nlm.nih.gov/pubmed/?term=24150595

 

Bio-microfluidic platform for gold nanoprobe based DNA detection—application to Mycobacterium tuberculosis.

Bernacka-Wojcik I, Lopes P, Vaz AC, Veigas B, Wojcik PJ, Simões P, Barata D, Fortunato E, Baptista PV, Águas H, Martins R. Biosens Bioelectron. 2013; 48:87-93.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23660340

 

New Clerodanes from Tinnea antiscorbutica Welv.

Borges C, Mendonça D, Fernandes N, Pinheiro S, Vieira L, Mendonça A, Gaspar JF, Martins C, Diakanawma C, Rueff J. J Braz Chem Soc. 2013; 24:1950-1956.

http://www.scielo.br/pdf/jbchs/v24n12/08.pdf

 

Plastic Compatible Sputtered Ta2O5 Sensitive Layer for Oxide Semiconductor TFT Sensors.

Branquinho R, Pinto JV, Busani T, Barquinha P, Pereira L, Baptista PV, Martins R, Fortunato E. J Display Technol. 2013; 9:723-728.

http://www.opticsinfobase.org/jdt/abstract.cfm?uri=jdt-9-9-723

 

The chemistry and biology of gold nanoparticle-mediated photothermal therapy: promises and challenges.

Cabral R, Baptista PV. Nano LIFE. 2013; 03(3):1330001.

http://www.worldscientific.com/doi/abs/10.1142/S179398441330001X

 

Association of FTO and PPARG polymorphisms with obesity in Portuguese women.

Carlos FF, Silva-Nunes J, Flores O, Brito M, Doria G, Veiga L, Baptista PV. Diabetes Metab Syndr Obes. 2013; 6:241-5.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23874114

 

Sickle cell disease severity scoring: a yet unsolved problem.

Coelho A, Dias A, Morais A, Nunes B, Faustino P, Lavinha J. Eur J Haematol. 2012; 89(6):501-2

http://www.ncbi.nlm.nih.gov/pubmed/22938536

 

Genetic variation in CD36, HBA, NOS3 and VCAM1 is associated with chronic haemolysis level in sickle cell anaemia: a longitudinal study.

Coelho A, Dias A, Morais A, Nunes B, Ferreira E, Picanço I, Faustino P, Lavinha J. Eur J Haematol. 2013; Oct 29. doi: 10.1111/ejh.12226. [Epub ahead of print].

http://onlinelibrary.wiley.com/doi/10.1111/ejh.12226/pdf

 

Genotoxic effect of exposure to metal(loid)s. A molecular epidemiology survey of populations living and working in Panasqueira Mine area, Portugal.

Coelho P, García-Lestón J, Costa S, Costa C, Silva S, Dall’Armi V, Zoffoli R, Bonassi St, Lima JP, Gaspar JF, Pásaro E, Laffon B, Teixeira JP. Environ Int. 2013; 60:163-70.

http://www.ncbi.nlm.nih.gov/pubmed/?term=24036326

 

 

Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea?

Conde J, de la Fuente JM, Baptista PV. Front Pharmacol. 2013; 4:134

http://www.ncbi.nlm.nih.gov/pubmed/24298255

 

 

Gold-Nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis.

Conde J, Larguinho M, Cordeiro A, Raposo LR, Costa PM, Santos S, Diniz M, Fernandes AR, Baptista PV. Nanotoxicology. 2014; 8(5):521-32. Epub 2013 May 28.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23642008

 

Gold-nanobeacons for simultaneous gene specific silencing and intracellular tracking of the silencing events.

Conde J, Rosa J, de la Fuente JM, Baptista PV. Biomaterials. 2013; 34(10):2516-23.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23312904

 

Multifunctional Gold Nanocarriers for Cancer Theranostics – From bench to bedside and back again?

Conde J, Tian F, Baptista PV, de la Fuente JM. Nano-Oncologicals. (2013) (Accepted).

 

In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models.

Conde J, Tian F, Hernández Y, Bao C, Cui D, Janssen KP, Ibarra MR, Baptista PV, Stoeger T, de la Fuente JM. Biomaterials 2013; 34(31):7744-53.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23850099

 

Coupling an universal primer to SBE combined spectral codification strategy for single nucleotide polymorphism analysis.

Cordeiro M, Giestas L, Lima JC, Baptista PV. J Biotechnol 2013; 168:90-4.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23942375

 

Co-segregation of trichorhinophalangeal syndrome with a t(8;13)(q23.3;q21.31) familial translocation that appears to increase TRPS1 gene expression.

David D, Marques B, Ferreira C, Araújo C, Vieira L, Soares G, Dias D, Pinto M. Hum Genet. 2013; 132(11):1287-99.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23835950

 

Integration of Gold nanoparticles and liposomes for combined anti-cancer drug delivery.

Figueiredo S, Cabral R, Luís D, Fernandes AR, Baptista PV. Nanomedicine. 2013. Editor: Professor Alexander Seifalian. One Central Press, Manchester, UK.

http://www.onecentralpress.com/nanomedicine/#

 

Instability of mRNA expression signatures of drug transporters in chronic myeloid leukemia patients resistant to imatinib.

Gromicho M, Magalhaes M, Torres F, Dinis J, Fernandes AR, Rendeiro P, Tavares P, Laires A, Rueff J, Rodrigues AS. Oncol Rep. 2013; 29:741-750.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23229016

 

Nucleotide identification using gold nanoparticle-based surface assisted laser desorption/ionisation.

Larguinho M, Capelo JL, Baptista PV. Talanta. 2013; 105: 417-421.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23598039

 

Histopathological findings on Carassius auratus hepatopancreas upon exposure to acrylamide: correlation with genotoxicity and metabolic alterations.

Larguinho M, Costa PM, Sousa G, Costa MH, Diniz MS, Baptista PV. J Appl Toxicol. 2013 Oct 7; doi: 10.1002/jat.2936. [Epub ahead of print].

http://www.ncbi.nlm.nih.gov/pubmed/?term=24122845

 

 

Genoma: bem público ou privado?

Lavinha J. In “Bem comum: Público e/ou Privado?” Pato J, Schmidt L, Gonçalves ME (eds). Imprensa de Ciências Sociais, Lisboa.

http://repositorio.insa.pt/bitstream/10400.18/1662/1/Genoma_p%C3%BAblico%20ou%20privado_Reposit%C3%B3rio_20130712.pdf

 

Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1.

Lopes A, Aston KI, Thompson EE, Carvalho F, Gonçalves J, Huang JN, Matthiesen R, Noordam MJ, Quintela I, Ramu A, Seabra C, Wilfert AB, Dai J, Downie J, Fernandes S, Guo X, Shah J, Amorim A, Barros A, Carracedo A. PLoS Genet. 2013; 9(3):e1003349.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23555275

 

Human exposure to indoor radon: a survey in the region of Guarda, Portugal.

Louro A, Peralta L, Soares S, Pereira A, Cunha G, Belchior A, Ferreira L, Monteiro Gil O, Louro H, Pinto P, Rodrigues AS, Silva MJ, Teles P. Radiat Prot Dosimetry. 2013; 154(2):237-44.

http://www.ncbi.nlm.nih.gov/pubmed/?term=22899215

 

Nanomateriais manufaturados – Novos desafios para a saúde pública.

Louro H, Borges T, Silva MJ. Revista Portuguesa de Saúde Pública. 2013; 31(2):145-157.

http://www.elsevier.es/eop/S0870-9025%2812%2900039-9.pdf

 

Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications.

Miranda HV, Xiang W, de Oliveira RM, Simões T, Pimentel J, Klucken J, Penque D, Outeiro TF. J Neurochem. 2013; 126(5):673-84.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23534813

 

Clinical proteomics stretch goals: EuPA 2012 roundtable report.

O’Neil SE, Palviainen MJ, Ten Have S, Filiou M, Gonzalez A, Hodge K, Surinova S, Penque D, Baker MS. J Proteomics. 2013; 88:37-40.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23597926

 

Effects of occupational exposure to tobacco smoke: is there a link between environmental exposure and disease?

Pacheco SA, Torres VM, Louro H, Gomes F, Lopes C, Marçal N, Fragoso E, Martins C, Oliveira CL, Hagenfeldt M, Bugalho-Almeida A, Penque D, Simões T. J Toxicol Environ Health A. 2013;76(4-5):311-27.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23514073

 

Functional characterization of eight human CYP1A2 variants: the role of cytochrome b5.

Palma BB, Silva e Sousa M, Urban P, Rueff J, Kranendonk M. Pharmacogenet Genomics. 2013; 23(2):41-52.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23295917

 

Induction of sister chromatid exchange by acrylamide and glycidamide in human lymphocytes: role of polymorphisms in detoxification and DNA-repair genes in the genotoxicity of glycidamide.

Pingarilho M, Oliveira NG, Martins C, Gomes BC, Fernandes AS, Martins V, Labilloy A, Lima JP, Rueff J, Gaspar JF. Mutat Res. 2013; 752(1-2): 1-7.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23376767

 

Human hepatoma cells exposed to sequential estuarine sediment contaminant extracts permitted the differentiation between cytotoxic and pro-mutagenic fractions.

Pinto M, Costa PM, Louro H, Costa MH, Lavinha J, Caeiro S, Silva MJ. Environ Pollut. 2014; 185:141-8. Epub 2013 Nov 24.

http://www.ncbi.nlm.nih.gov/pubmed/?term=24275312

 

Lack of Relevance of HIF-1 alfa Polymorphisms in Breast Cancer in a Portuguese Population.

Ribeiro AL, Gaspar JF, Pereira T, Ribeiro V. Anticancer Res. 2013; 33(6):2549-55.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23749907

 

Efficient IDUA Gene Mutation Detection with Combined Use of dHPLC and Dried Blood Samples.

Ribeiro D, Cardoso A, Duarte AJ, Vieira L, Amaral O. ISRN Molecular Biology 2013: Article ID 451298, 4 pages.

http://dx.doi.org/10.1155/2013/451298

 

 

 

DNA Repair and Resistance to Cancer Therapy.

Rodrigues AS, Gomes BC, Martins C, Gromicho M, Oliveira NG, Guerreiro PS, Rueff J. In “New Research Directions in DNA Repair” (C. Chen Ed.). Intech Press. Pp. 489-528.

http://www.intechopen.com/books/new-research-directions-in-dna-repair/dna-repair-and-resistance-to-cancer-therapy

 

The role of CCNH Val270Ala (rs2230641) and other nucleotide excision repair polymorphisms on individual susceptibility towards well-differentiated thyroid cancer.

Santos LS, Gomes BC,Gouveia R, Silva SN, Azevedo AP, Camacho V, Manita I, Gil OM, Ferreira TC, Limbert E, Rueff J, Gaspar JF. Oncol Rep. 2013;30(5):2458-66

http://www.ncbi.nlm.nih.gov/pubmed/?term=23982724

 

A possible approach for gel-based proteomic studies in recalcitrant woody plants.

Sebastiana M, Figueiredo A, Monteiro F, Martins J, Franco C, Coelho AV, Vaz F, Simões T, Penque D, Pais MS, Ferreira S. Springerplus. 2013; 2(1):210

http://www.ncbi.nlm.nih.gov/pubmed/?term=23724367

 

Predominance of constitutional chromosomal rearrangements in human chromosomal fragile sites.

Sequeira IJ, Mexia JT, Santiago J, Mamede R, Silva E, Santos J, Faria D, Rueff J, Brás A. Open Journal of Genetics.  2013; 3: 8-13.

http://www.scirp.org/journal/PaperInformation.aspx?paperID=35027#.UupWBbSUa0Y

 

Proteoform: a single term describing protein complexity.

Smith LM, Kelleher NL, Consortium for Top Down Proteomics: Linial M, Goodlett D, Langridge-Smith P, Goo YA, Safford G, Bonilla L, Kruppa G, Zubarev R, Rontree J, Chamot-Rooke J, Garavelli J, Heck A, Loo J, Penque D, Hornshaw M, Hendrickson C, Pasa-Tolic L, Borchers C, Chan D, Young N, Agar J, Masselon C, Gross M, McLafferty F, Tsybin Y, Ge Y, Sanders I, Langridge J, Whitelegge J, Marshall A. Nat Methods. 2013; 10(3):186-7.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23443629

 

Genotoxicity evaluation of nanosized titanium dioxide, synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes,

Tavares A, Louro H, Antunes S, Quarré S, Simar S, Temmerman PD, Verleysen E, Mast J, Jensen KA, Norppa H, Nesslany F, Silva MJ. Toxicol In Vitro. 2014; 28(1):60-9. Epub 2013 Jun 27.

http://dx.doi.org/10.1016/j.tiv.2013.06.009

 

Multi-mycotoxin determination and in vitro combined cytotoxic effects of aflatoxin M1 and ochratoxin A.

Tavares AM, Alvito P, Loureiro S, Louro H, Silva MJ. World Mycotoxin Journal. 2013; 6: 375-388.

http://repositorio.insa.pt/handle/10400.18/1792

 

Ion sensing (EIS) real-time quantitative monitorization of isothermal DNA amplification.

Veigas B, Branquinho R, Pinto JV, Wojcik PJ, Martins R, Fortunato E, Baptista PV. Biosens Bioelectron. 2014; 52:50-5. Epub 2013 Aug 24.

http://www.ncbi.nlm.nih.gov/pubmed/?term=24021655

 

Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis.

Veigas B, Pedrosa P, Couto I, Viveiros M, Baptista PV. J Nanobiotechnology. 2013; 11:38.

http://www.ncbi.nlm.nih.gov/pubmed/24274610

 

 

2012

 

RNA Quantification with Gold Nanoprobes for Cancer Diagnostics.

Baptista PV. Clinics in Laboratory Medicine 2012; 32(1):1-13.

http://www.sciencedirect.com/science/article/pii/S0272271211000989

 

 

 

Design of Multifunctional Gold Nanoparticles for In Vitro and In Vivo Gene Silencing.

Conde J, Ambrosone A, Sanz V, Hernandez Y, Marchesano V, Tian F, Child H, Berry CC, Ibarra MR, Baptista PV, Tortiglione C, de la Fuente JM. ACS Nano. 2012; 6(9):8316-24.

http://www.ncbi.nlm.nih.gov/pubmed/22882598

 

Modification of plasmid DNA topology by ‘histone-mimetic’ gold nanoparticles.

Conde J, Baptista PV, Hernández Y, Sanz V, de la Fuente JM. Nanomedicine (Lond). 2012; 7(11):1657-66.

http://www.ncbi.nlm.nih.gov/pubmed/22583575

 

Noble Metal Nanoparticles Applications in Cancer.

Conde J, Doria G, Baptista P. Journal of Drug Delivery 2012; 2012:ID751075, 12 pages.

http://www.hindawi.com/journals/jdd/2012/751075/

 

RNA quantification using noble metal nanoprobes: simultaneous identification of several different mRNA targets using color multiplexing and application to cancer diagnostics.

Conde J, Doria G, de la Fuente JM, Baptista PV. Methods Mol Biol. 2012; 906:71-87.

http://www.ncbi.nlm.nih.gov/pubmed/22791425

 

Nanophotonics for Molecular Diagnostics and Therapy Applications.

Conde J, Rosa J, Lima JC, Baptista PV. International Journal of Photoenergy 2012; 2012:ID 619530, 11 pages.

http://www.hindawi.com/journals/ijp/2012/619530/

 

DNA damage and susceptibility assessment in industrial workers exposed to styrene.

Costa CST, Costa S, Silva S, Coelho P, M. Botelho M, Gaspar JF, Rueff J, Laffon B, Teixeira JP. Toxicol Environ Health A. 2012;75(13-15):735-46.

http://www.ncbi.nlm.nih.gov/pubmed/22788361

 

DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells,

Dinis J, Silva V, Gromicho M, Martins C, Laires A, Tavares P, Rendeiro P, Torres F, Rueff J, Rodrigues A.  Leuk Lymphoma. 2012; 53(10):2004-14.

http://www.ncbi.nlm.nih.gov/pubmed/22475343

 

Noble Metal Nanoparticles for Biosensing Applications.

Doria G, Conde J, Veigas B, Giestas L, Almeida C, Assunção M, Rosa J, Baptista PV. Sensors 2012; 12(2), 1657-1687.

http://www.mdpi.com/1424-8220/12/2/1657

 

Pneumocystis jirovecii multilocus genotyping in pooled DNA samples: a new approach for clinical and epidemiological studies,

Esteves F, Gaspar JF, de Sousa B, Antunes F, Mansinho K, Matos O. Clin Microbiol Infect. 2012; 18(6):E177-84.

http://www.ncbi.nlm.nih.gov/pubmed/22487139

 

 

Development of pyridine-containing macrocyclic copper(II) complexes: potential role in the redox modulation of oxaliplatin toxicity in human breast cells.

Fernandes AS, Costa J, Gaspar JF, Rueff J, Cabral MF, Castro M, Oliveira NG. Free Radic Res. 2012; 46(9):1157-66.

http://www.ncbi.nlm.nih.gov/pubmed/22612279

 

Genotoxic effects of occupational exposure to lead and influence of polymorphisms in genes involved in lead toxicokinetics and in DNA repair.

García-Lestón J, Roma-Torres J, Vilares M, Pinto R, Prista J, Teixeira JP, Mayan O, Conde J, Pingarilho M, Gaspar JF, Pásaro E, Méndez J, Laffon B. Environ Int. 2012; 43:29-36.

http://www.ncbi.nlm.nih.gov/pubmed/22466227

 

 

 

Instability of mRNA expression signatures of drug transporters in chronic myeloid leukemia patients resistant to imatinib.

Gromicho M, Magalhaes M,  Torres F, Dinis J, Fernandes AR, Rendeiro P, Tavares P, Laires A, Rueff J, Rodrigues AS. Oncol Rep. 2013; 29(2):741-50. Epub 2012 Nov 28.

http://www.ncbi.nlm.nih.gov/pubmed/23229016

 

Gold nanoparticle-based fluorescence immunoassay for Malaria antigen detection.

Guirgis BSS, Sá e Cunha C, Gomes I, Cavadas M, Silva I, Doria G, Blatch GL, Baptista PV, Pereira E, Azzazy HME, Mota MM, Prudêncio M, Franco R. Anal Bioanal Chem. 2012; 402(3):1019-27.

http://www.ncbi.nlm.nih.gov/pubmed/22089818

 

Gold and silver nanoparticles for clinical diagnostics — From genomics to proteomics.

Larguinho M, Baptista PV. J Proteomics. 2012; 75(10):2811-23.

http://www.ncbi.nlm.nih.gov/pubmed/22119545

 

Human Exposure to Indoor Radon: A Survey in the Region of Guarda, Portugal.

Louro A, Peralta L, Soares S, Pereira A, Cunha G, Belchior A, Ferreira L, Gil OM, Louro H, Pinto P, Rodrigues AS, SIlva MJ, Teles P. Radiat Prot Dosimetry. 2013; 154(2):237-44. Epub 2012 Aug 16.

http://www.ncbi.nlm.nih.gov/pubmed/22899215

 

Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.

Machado D, I. Couto I, Perdigão J, Rodrigues L, Portugal I, Baptista P, Veigas B, Amaral L, Viveiros M. PLoS ONE. 2012; 7(4):e34538.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0034538

 

Genetic polymorphisms in detoxification and DNA repair genes and in vitro susceptibility to glycidamide-induced DNA damage.

Pingarilho M, Oliveira NG, Martins C, AS. Fernandes, Lima JP, Rueff J, Gaspar JF. J Toxicol Environ Health A. 2012; 75(13-15):920-33.

http://www.ncbi.nlm.nih.gov/pubmed/22788377

 

Genomics and Cancer Drug Resistance.

Rodrigues AS, Dinis J, Gromicho M. Martins M, Laires A, Rueff J. Curr Pharm Biotechnol. 2012; 13(5):651-73.

http://www.ncbi.nlm.nih.gov/pubmed/22122479

 

Gold-nanobeacons for real-time monitoring of RNA synthesis.

Rosa J, Conde J, De la Fuente JM, Lima JC, Baptista PV. Biosens Bioelectron. 2012; 36(1):161-7.

http://www.ncbi.nlm.nih.gov/pubmed/22541812

 

Genotoxic damage in hospital workers exposed to ionizing radiation and metabolic gene polymorphisms.

Sakly A, Gaspar JF, Kerkeni E, Silva S, Teixeira JP, Chaari N, Cheikh HB. J Toxicol Environ Health A. 2012; 75(13-15):934-46.

http://www.ncbi.nlm.nih.gov/pubmed/22788378

 

Enhancement of antibiotic effect via gold: silver alloy nanoparticles.

Santos MM, Queiroz MJ, Baptista PV. Journal of Nanoparticle Research. 2012; 14:859-67.

http://link.springer.com/article/10.1007%2Fs11051-012-0859-8

 

Effect of PEG biofunctional spacers and TAT peptide on dsRNA loading on gold nanoparticles.

Sanz V, Conde J, Hernández Y, Baptista PV, Ibarra MR, De la Fuente JM. Journal of Nanoparticle Research. 2012; 14:917-26.

http://link.springer.com/article/10.1007/s11051-012-0917-2

 

SNPs/Pools: A methodology for the identification of relevant SNPs in breast cancer epidemiology,

Silva SN, D. Guerreiro D, Gomes M, A.P. Azevedo AP, De Castro GB, Rueff J, Gaspar JF. Oncol Rep. 2012; 27(2):511-6.

http://www.ncbi.nlm.nih.gov/pubmed/22024983

Brassica oleracea L. Var. costata DC and Pieris brassicae L. Aqueous Extracts Reduce Methyl Methanesulfonate-Induced DNA Damage in V79 Hamster Lung Fibroblasts,

Sousa C, Fernandes F, Valentão P, Rodrigues AS, Coelho M, Teixeira JP, Silva S, Ferreres F, de Pinho PG, Andrade PB. J Agric Food Chem. 2012; 60(21):5380-7.

http://www.ncbi.nlm.nih.gov/pubmed/22582708

 

Nanodiagnostics for tuberculosis

Veigas B, Doria G, Baptista PV. In “Understanding Tuberculosis – Global Experiences and Innovative Approaches to the Diagnosis”. 2012; Pages 257-276, ISBN 979-953-307-078-9. Open Access Publishers.

http://www.intechopen.com/books/understanding-tuberculosis-global-experiences-and-innovative-approaches-to-the-diagnosis/nanodiagnostics-for-tuberculosis

 

Gold on Paper – Paper platform for Aunanoprobe TB detection.

Veigas B, Jacob J, Costa M, Santos D, Viveiros M, Inácio J, Martins R, Barquinha P, Fortunato E, Baptista PV. Lab Chip. 2012; 12(22):4802-8.

http://www.ncbi.nlm.nih.gov/pubmed/23000923

 

Nanoparticles in Molecular Diagnostics

Baptista PV, Doria G, Quaresma P, Cavadas M, Neves CS, Gomes I, Eaton P, Pereira E, Franco R. In “Progress in Molecular Biology and Translational Science”, 2011; Ed. A. Villaverde, Ed. P. Michael Conn, Elsevier Vol 104, Pages 427-488.

http://www.sciencedirect.com/science/bookseries/18771173/104/supp/C

 

 

2011

 

Real-time monitoring of PCR amplification of proto-oncogene c-MYC using a Ta2O5 electrolyte–insulator–semiconductor sensor.

Branquinho R, Veigas B, Pinto JV, Martins R, Fortunato E, Baptista PV. Biosens Bioelectron. 2011; 28(1):44-9

http://www.ncbi.nlm.nih.gov/pubmed/21802276

 

ACMA (9-amino-6-chloro-2-methoxy acridine) forms three complexes in presence of DNA.

Busto N, García B, Leal JM, Gaspar JF, Martins C, Boggioni A, Secco F. Phys Chem Chem Phys. 2011; 13(43):19534-45

http://www.ncbi.nlm.nih.gov/pubmed/?term=21971327

 

Preparation of Organometallic Ruthenium Arene Diaminotriazine Complexes as Binding Agents.

Busto N, Valladolid J, Aliende C, Jalón FA, Manzano BR, Rodríguez A, Gaspar JF, Martins C, Biver T, Espino G, Leal JM, García B. Chem Asian J. 2012; 7(4):788-801

http://www.ncbi.nlm.nih.gov/pubmed/22308008

 

Effect of kidney disease on glucose handling (including genetic defects),

Calado J, R. Santer, Rueff J. Kidney Int Suppl. 2011; (120):S7-13

http://www.ncbi.nlm.nih.gov/pubmed/?term=21358700

 

Serum proteomics signature of Cystic Fibrosis patients: A complementary 2-DE and LC-MS/MS approach.

Charro N, Hood BL, Faria D, Pacheco P, Azevedo P, Lopes C, de Almeida AB, Couto FM, Conrads TP, Penque D. J Proteomics, 74:110-26.

http://www.ncbi.nlm.nih.gov/pubmed/?term=20950718

 

 

 

RNA quantification using noble metal nanoprobes -application to cancer diagnostics.

Conde J, Doria G, De la Fuente JM, Baptista PV. Chapter 29. In “Nanoparticles in Biology and Medicine – Methods and Applications”, 2011. Humana Press, USA (Springer Science + Business Media)

http://link.springer.com/protocol/10.1007/978-1-61779-953-2_6

 

The transition of the European Proteomics Association into the future.

Corthals GL, Dunn M, James P, Gil C, Penque D, Albar JP, Andrén P, Rabilloud T, Marko-Varga G. J Proteomics. 2011; 75(1):18-22.

http://www.ncbi.nlm.nih.gov/pubmed/21726672

 

Facing challenges in Proteomics today and in the coming decade: Report of Roundtable Discussions at the 4th EuPA Scientific Meeting, Portugal, Estoril 2010.

Cox J, Heeren RM, James P, Jorrin-Novo JV, Kolker E, Levander F, Morrice N, Picotti P, Righetti PG, Sánchez JC, Turck CW, Zubarev R, Alexandre BM, Corrales FJ, Marko-Varga G, O’Donovan S, O’Neil S, Prechl J, Simões T, Weckwerth W, Penque D. J Proteomics. 2011; 75(1):4-17.

http://www.ncbi.nlm.nih.gov/pubmed/?term=21571109

 

Genetic defects in Portuguese families with inherited protein C deficiency.

David D, Ferreira C, Ventura C, Freire I, Moreira I, Gago T. Thromb Res. 2011; 128(3):299-302

http://www.ncbi.nlm.nih.gov/pubmed/?term=21621249

 

Clinical relevance of multiple single-nucleotide polymorphisms in Pneumocystis jirovecii Pneumonia: development of a multiplex PCR-single-base-extension methodology,

Esteves F, Gaspar JF, De Sousa B, Antunes F, Mansinho K, Matos O. J Clinic Microbiol. 2011; 49:1810-1815.

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Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach.

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Coupling single base extension to a spectral codification tool for increased throughput screening.

Giestas L, Lima JC, Baptista PV. J Biotechnol. 2011; 154:199-204.

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Signaling pathways of proteostasis network unraveled by proteomic approaches on the understanding of misfolded protein rescue.

Gomes-Alves P, Neves S, Penque D. In “Methods in Enzymology: The Unfolded Protein Response and Cellular Stress”, Part C, 2011. Edited by P. Michael Conn, volume 491:217-233.

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Development of imatinib and dasatinib resistance: dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1,

Gromicho M, Dinis J, M. Magalhaes M, Fernandes AR, Tavares P, Laires A, Rueff J, Rodrigues AS. Leuk Lymphoma. 2011; 52(10):1980-90.

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Cost/benefit of mutation induction under PARP1 deficiency: from genomic instability to therapy.

Louro H, Silva MJ. In “Advances in Genetics Research” Vol 4. Kevin V. Urbano (ed.), Nova Publishers, Inc., NY, U.S.A, pp. 109-134.

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Immune cells and hepatocytes express glycosylphosphatidylinositol-anchored ceruloplasmin at their cell surface.

Marques L, Auriac A, Willemetz A, Banha J, Silva B, Canonne-Hergaux F, Costa L. Blood Cells Mol Dis. 2012; 48(2):110-20.

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Genotoxic and apoptotic activities of the food flavourings myristicin and eugenol in AA8 and XRCC1 deficient EM9 cells

Martins C, Doran C, Laires A, Rueff J, Rodrigues AS. Food Chem Toxicol. 2011; 49(2):385-92.

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Differential HFE gene expression is regulated by alternative splicing in human tissues.

Martins R, Silva R, Proença D, Faustino P. PLoS One. 2011; 6(3): e17542.

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Molluscicidal Activity of Compounds Isolated from Euphorbia conspicua N. E. Br.

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Proteomics Odissey Towards Next Decades,

Penque D, Simões T, Amado F (Edt). J Proteomics. 2011; 75(1):1-316

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Proteomics advances in the last decade: What is next?

Penque D, Simões T, Amado F. J Proteomics. 2011; 75(1):1-3

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Genotoxic effects of doxorubicin in cultured human lymphocytes with different glutathione S-transferase genotypes

Ramos DL, Gaspar JF, Pingarilho M, Gil OM, Fernandes AS, Rueff J, Oliveira NG. Mutat Res. 2011; 724(1-2):28-34

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Experimental photophysical characterization of fluorophores on the vicinity of gold nanoparticles – deciphering disputes related to kr determination.

Rosa JP, Lima JC, Baptista PV. Nanotechnology. 2011; 22(41):415202

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Portable optoelectronic biosensing platform for identification of mycobacteria from the Mycobacterium tuberculosis complex.

Silva LB, Veigas B, Doria G, Costa P, Inácio J, Martins R, Fortunato E, Baptista PV.. Biosens Bioelectron. 2011; 26(5): 2012-7.

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Molecular profiling of the human nasal epithelium: A proteomics approach.

Simões T, Charro N, Blonder J, Faria D, Couto FM, Chan KC, Waybright T, Isaaq HJ, Veenstra TD, Penque D. J Proteomics. 2011; 75(1):56-69

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Supramolecular organizations in the aerobic respiratory chain of Escherichia coli.

Sousa PM, Silva ST, Hood BL, Charro N, Carita JN, Vaz F, Penque D, Conrads TP, Melo AM. Biochimie, 2011; 93:418-25.

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Identification of SOX3 as an XX male sex reversal gene in mice and humans.

Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, Rogers N, Knower K, Rowley L, Eyre H, Rizzoti K, McAninch D, Gonçalves J, Slee J, Turbitt E, Bruno D, Bengtsson H, Harley V, Vilain E, Sinclair A, Lovell-Badge R, Thomas P. J Clin Invest. 2011; 121(1):328-41

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Solubilization of fullerene C60 in micellar solutions of different solubilizers.

Torres VM, Posa M, Srdjenovic B, Simplício AL. Colloids Surf B Biointerfaces. 2011; 82(1):46-53.

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