Projects ToxOmics 2011-2015

EU FPQ ERANET – NanoSciera+Nanotruck –“Multifunctional Gold Nanoparticles for Gene Therapy.”

EU FP7 – “NANoREG – A common European Approach to the Regulatory Testing of Nanomaterials.”

EU Executive Agency for Health and Consumers – “NANOGENOTOX – Safety Evaluation of Manufactured Nanomaterials by Characterisation of their Potential Genotoxic Hazard.”

EU FP7 – THEME [SME-2012-1] [Research for SMEs] RTD. “Lung Card – Point-of-care blood device for fast and reliable prediction of drug response in non- small-cell lung carcinoma patients from blood samples.”

Harvard Medical School- Portugal Program – “Obstructive sleep apnea and associated metabolic/cardiovascular disorders: understanding mechanisms towards early diagnosis and prognosis prediction.”

NIH – AGREEMENT NO 126759/125701. “Molecular and cellular effects of human mutations in cytochrome P450 reductase”

FCT – “Development and validation of vaso-occlusion early predictors in a Mendelian model of vascular
disease.”

FCT – “HERA – Environmental Risk Assessment of a Contaminated Estuarine Environment: a Case Study.”

FCT – “Mycomix – Exploring the toxic effects of mixtures of mycotoxins in infant food and potential health impact.”

FCT – “Patogénese molecular de “doenças de cis-rupção” associadas a translocações cromossómicas.”

FCT – “Role of the iron metabolism on the progression of hepatitis C viral infection and treatment response.”

FCT – “Translational regulation of human erythropoietin (EPO) by an upstream open reading frame (uORF) and its impact on myocardial ischemia.”

FCT – PTDC/BBB-NAN/1812/2012 – “Silence is golden (siAu) – silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy.”

FCT – PTDC/BIA-MIC/71280/2006 – “Mutational and physiological dynamics of drug resistance in Mycobacterium tuberculosis: the emergence of Multi-Drug Resistant Tuberculosis.”

FCT – PTDC/BIO/66514/2006 – “Sensitive and selective detection of DNA/RNA based on functionalised gold nanoparticles.”

FCT – PTDC/CTM-NAN/109877/2009 – “Multifunctional Nanoparticles for Clinical Diagnosis.”

FCT – PTDC/CVT/111634/2009 – “zoonTB – Improved NAT-based approaches to detect and discriminate animal-associated Mycobacterium tuberculosis Complex members and evaluation of the zoonotic potential of these species in Portugal.”

FCT – PTDC/EEA-ELC/74236/2006 – “Novel Advanced Integrated Optical Nano-Sensors Systems for Nanobiodetection, based on gold nanoparticle probes: NANOSEN.”

FCT – PTDC/FIS/74274/2006 – “Nanobiodetection based on optical nano-sensors and gold nanoparticles probe Systems: NANOBIOS.”

FCT – PTDC/QUI/64484/2006 – “Metal- and magnetic nanoparticles functionalized with biological molecules: towards bio-nanoprobes.”

FCT – PTDC/QUI/66813/2006. “Estudos Químicos, Radioquímicos e Biológicos de Complexos de Pt (II) com Ligandos Pirazolo-Alquilamina: Aplicações no Desenvolvimento de Novos Agentes Anti-cancerígenos.”

FCT – PTDC/QUI/67522/2006. “Novos SERMs bio-organometálicos – síntese e avaliação do potencial anti-cancerígeno.”

FCT – PTDC/QUI-QUI/112597/2009 – “NANOLIGHT – Nanosystems for delivery of caged compounds.”

FCT – PTDC/QUI-QUI/113910/2009. “Mecanismos de bioactivação do fármaco anti-HIV Nevirapina: identificação de metabolitos reactivos e potencial mutagénico”

FCT – PTDC/SAU-BEB/098125/2008 – “Portable nano/micro-biosensor platform for ultrasensitive multidetection in blood samples – BloodFET.”

FCT – PTDC/SAU-BEB/66511/2006 – “Nanodiagnostics: gold-nanoprobes for molecular recognition – application to DNA adducts detection; pathogen detection; gene expression and RNA quantification.”

FCT – PTDC/SAU-ESA/102367/2008. “GenFA- Exposição Ocupacional ao Formaldeído. Análise do dano genético e susceptibilidade genética em profissionais dos serviços de Anatomia Patológica.”

FCT – PTDC/SAU-GMG/71720/2006. “Mecanismos de Resistência ao Imatinib em Leucemia Mielóide Crónica.”

FCT – PTDC/SAU-GMG/71911/2006. “O estudo de mutações relacionadas com o Síndroma Antley-Bixler na oxireductase do citocromo P450: polimorfismo do CYPOR e o complexo enzimático do citocromo P450.”

FCT – PTDC/SAU-MIC/116716/2010. “Relevância clínica de múltiplos marcadores genéticos na pneumonia por Pneumocystis jirovecii (PPc): Novas metodologias de alto rendimento para aplicação à epidemiologia molecular e diagnóstco”

FCT – PTDC/SAU-MII/104231/2008. “Importância do B-glucano na Pneumonia por Pneumocystis jirovecii (PPc): Uma nova ferramenta de diagnóstico.”

FCT – PTDC/SAU-OSM/105572/2008. “Biomarcadores de exposição alimentar à acrilamida: relevância toxicológica para o homem.”

FCT Transnational Program – Portugal-Serbia – “Herbal remedies – mechanism of action and potential herb-drug interactions.”

FCGulbenkian & ACSS – “Tobacco smoke in leisure spaces: healthy and molecular damage effects.”

FLAD – “The role of mRNA translation on nonsense-mediated decay inhibition as a modifier of human genetic disorders due to nonsense mutations.”

ASTRAZENECA – DAPA/SGI.T2 INVESTIGATION PROJECT. “Development of a Cellular Model for Familial Renal Glicosuria: Evaluation of Mutants and Implications for the Treatment of Type 2 Diabetes Mellitus”

BIOSTRUMENT-Consultadoria e desenvolvimento de projectos bioquímicos, S.A. “Estudo da toxicidade e genotoxicidade de quitosanos”

Fundação Merck, Sharp & Dohme – “Identification of new proteins involved in colorectal cancer due to internal ribosome entry site (IRES)-mediated translation.”

Escola Superior de Biotecnologia da UCP. “Estudo de genotoxicidade de duas amostras de produtos petrolíferos”